Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for Autoregulation

Guanine nucleotide exchange factors (GEFs) catalyze exchange of GDP for GTP by stabilizing the nucleotide-free state of the small GTPases through their Dbl homology/pleckstrin homology (DH·PH) domains. Unconventionally, PDZ-RhoGEF (PRG), a member of the RGS-RhoGEFs, binds tightly to both nucleotide-...

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Autori principali: Chen, Zhe, Medina, Frank, Liu, Mu-ya, Thomas, Celestine, Sprang, Stephen R., Sternweis, Paul C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898337/
https://ncbi.nlm.nih.gov/pubmed/20430886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122549
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