Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF

Small guanosine triphosphatases (GTPases) become activated when GDP is replaced by GTP at the highly conserved nucleotide binding site. This process is intrinsically very slow in most GTPases but is significantly accelerated by guanine nucleotide exchange factors (GEFs). Nucleotide exchange in small...

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Detalhes bibliográficos
Main Authors: Gasmi-Seabrook, Geneviève M. C., Marshall, Christopher B., Cheung, Melissa, Kim, Bryan, Wang, Feng, Jang, Ying Ju, Mak, Tak W., Stambolic, Vuk, Ikura, Mitsuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820740/
https://ncbi.nlm.nih.gov/pubmed/20018869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064691
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