Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF

Small guanosine triphosphatases (GTPases) become activated when GDP is replaced by GTP at the highly conserved nucleotide binding site. This process is intrinsically very slow in most GTPases but is significantly accelerated by guanine nucleotide exchange factors (GEFs). Nucleotide exchange in small...

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Bibliografske podrobnosti
Main Authors: Gasmi-Seabrook, Geneviève M. C., Marshall, Christopher B., Cheung, Melissa, Kim, Bryan, Wang, Feng, Jang, Ying Ju, Mak, Tak W., Stambolic, Vuk, Ikura, Mitsuhiko
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820740/
https://ncbi.nlm.nih.gov/pubmed/20018869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064691
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