Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF

Small guanosine triphosphatases (GTPases) become activated when GDP is replaced by GTP at the highly conserved nucleotide binding site. This process is intrinsically very slow in most GTPases but is significantly accelerated by guanine nucleotide exchange factors (GEFs). Nucleotide exchange in small...

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Autori principali: Gasmi-Seabrook, Geneviève M. C., Marshall, Christopher B., Cheung, Melissa, Kim, Bryan, Wang, Feng, Jang, Ying Ju, Mak, Tak W., Stambolic, Vuk, Ikura, Mitsuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820740/
https://ncbi.nlm.nih.gov/pubmed/20018869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064691
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