The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the mouse, we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11) in white ad...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Chang, Ying-Ju, Pownall, Scott, Jensen, Thomas E, Mouaaz, Samar, Foltz, Warren, Zhou, Lily, Liadis, Nicole, Woo, Minna, Hao, Zhenyue, Dutt, Previn, Bilan, Philip J, Klip, Amira, Mak, Tak, Stambolic, Vuk
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2015
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709268/
https://ncbi.nlm.nih.gov/pubmed/26512886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06011
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires