The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the mouse, we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11) in white ad...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Chang, Ying-Ju, Pownall, Scott, Jensen, Thomas E, Mouaaz, Samar, Foltz, Warren, Zhou, Lily, Liadis, Nicole, Woo, Minna, Hao, Zhenyue, Dutt, Previn, Bilan, Philip J, Klip, Amira, Mak, Tak, Stambolic, Vuk
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2015
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709268/
https://ncbi.nlm.nih.gov/pubmed/26512886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06011
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