The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the mouse, we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11) in white ad...

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Vydáno v:eLife
Hlavní autoři: Chang, Ying-Ju, Pownall, Scott, Jensen, Thomas E, Mouaaz, Samar, Foltz, Warren, Zhou, Lily, Liadis, Nicole, Woo, Minna, Hao, Zhenyue, Dutt, Previn, Bilan, Philip J, Klip, Amira, Mak, Tak, Stambolic, Vuk
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709268/
https://ncbi.nlm.nih.gov/pubmed/26512886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06011
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