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Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42
Gα proteins promote dynamic adjustments of cell shape directed by actin-cytoskeleton reorganization via their respective RhoGEF effectors. For example, Gα(13) binding to the RGS-homology (RH) domains of several RH-RhoGEFs allosterically activates these proteins, causing them to expose their catalyti...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7863908/ https://ncbi.nlm.nih.gov/pubmed/33023908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC120.015204 |
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