Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42

Gα proteins promote dynamic adjustments of cell shape directed by actin-cytoskeleton reorganization via their respective RhoGEF effectors. For example, Gα(13) binding to the RGS-homology (RH) domains of several RH-RhoGEFs allosterically activates these proteins, causing them to expose their catalyti...

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Publié dans:J Biol Chem
Auteurs principaux: Castillo-Kauil, Alejandro, García-Jiménez, Irving, Cervantes-Villagrana, Rodolfo Daniel, Adame-García, Sendi Rafael, Beltrán-Navarro, Yarely Mabell, Gutkind, J. Silvio, Reyes-Cruz, Guadalupe, Vázquez-Prado, José
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863908/
https://ncbi.nlm.nih.gov/pubmed/33023908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC120.015204
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