PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation

G protein-coupled receptors (GPCRs) linked to both members of the Gα(12) family of heterotrimeric G proteins α subunits, Gα(12) and Gα(13), regulate the activation of Rho GTPases, thereby contributing to many key biological processes. Multiple Rho GEFs have been proposed to link Gα(12/13) GPCRs to R...

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Detalhes bibliográficos
Main Authors: Mikelis, Constantinos M., Palmby, Todd R., Simaan, May, Li, Wenling, Szabo, Roman, Lyons, Ruth, Martin, Daniel, Yagi, Hiroshi, Fukuhara, Shigetomo, Chikumi, Hiroki, Galisteo, Rebeca, Mukouyama, Yoh-suke, Bugge, Thomas H., Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636907/
https://ncbi.nlm.nih.gov/pubmed/23467409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428599
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