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Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42

Gα proteins promote dynamic adjustments of cell shape directed by actin-cytoskeleton reorganization via their respective RhoGEF effectors. For example, Gα(13) binding to the RGS-homology (RH) domains of several RH-RhoGEFs allosterically activates these proteins, causing them to expose their catalyti...

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Pubblicato in:J Biol Chem
Autori principali: Castillo-Kauil, Alejandro, García-Jiménez, Irving, Cervantes-Villagrana, Rodolfo Daniel, Adame-García, Sendi Rafael, Beltrán-Navarro, Yarely Mabell, Gutkind, J. Silvio, Reyes-Cruz, Guadalupe, Vázquez-Prado, José
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863908/
https://ncbi.nlm.nih.gov/pubmed/33023908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC120.015204
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