The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the mouse, we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoGEF (Arhgef11) in white ad...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chang, Ying-Ju, Pownall, Scott, Jensen, Thomas E, Mouaaz, Samar, Foltz, Warren, Zhou, Lily, Liadis, Nicole, Woo, Minna, Hao, Zhenyue, Dutt, Previn, Bilan, Philip J, Klip, Amira, Mak, Tak, Stambolic, Vuk
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709268/
https://ncbi.nlm.nih.gov/pubmed/26512886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06011
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