Activation of p115-RhoGEF Requires Direct Association of Gα(13) and the Dbl Homology Domain

RGS-containing RhoGEFs (RGS-RhoGEFs) represent a direct link between the G(12) class of heterotrimeric G proteins and the monomeric GTPases. In addition to the canonical Dbl homology (DH) and pleckstrin homology domains that carry out the guanine nucleotide exchange factor (GEF) activity toward RhoA...

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Detalhes bibliográficos
Principais autores: Chen, Zhe, Guo, Liang, Hadas, Jana, Gutowski, Stephen, Sprang, Stephen R., Sternweis, Paul C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408165/
https://ncbi.nlm.nih.gov/pubmed/22661716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333716
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