Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for Autoregulation

Guanine nucleotide exchange factors (GEFs) catalyze exchange of GDP for GTP by stabilizing the nucleotide-free state of the small GTPases through their Dbl homology/pleckstrin homology (DH·PH) domains. Unconventionally, PDZ-RhoGEF (PRG), a member of the RGS-RhoGEFs, binds tightly to both nucleotide-...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Chen, Zhe, Medina, Frank, Liu, Mu-ya, Thomas, Celestine, Sprang, Stephen R., Sternweis, Paul C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898337/
https://ncbi.nlm.nih.gov/pubmed/20430886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122549
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы