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Targeting G protein-coupled receptor signalling by blocking G proteins
G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to their druggability, diversity and physiological efficacy. Many drugs selectively target specific subtypes of GPCRs, but high specificity for individual GPCRs may not be desirable in complex multifactorial dis...
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| Publicado no: | Nat Rev Drug Discov |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6409483/ https://ncbi.nlm.nih.gov/pubmed/30262890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd.2018.135 |
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