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Rational Design of a Selective Covalent Modifier of G Protein βγ Subunits
G protein-coupled receptors transduce signals through heterotrimeric G protein Gα and Gβγ subunits, both of which interact with downstream effectors to regulate cell function. Gβγ signaling has been implicated in the pathophysiology of several diseases, suggesting that Gβγ could be an important phar...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014279/ https://ncbi.nlm.nih.gov/pubmed/20881007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.068155 |
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