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Rational Design of a Selective Covalent Modifier of G Protein βγ Subunits

G protein-coupled receptors transduce signals through heterotrimeric G protein Gα and Gβγ subunits, both of which interact with downstream effectors to regulate cell function. Gβγ signaling has been implicated in the pathophysiology of several diseases, suggesting that Gβγ could be an important phar...

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Detalhes bibliográficos
Main Authors: Dessal, Axel L., Prades, Roger, Giralt, Ernest, Smrcka, Alan V.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014279/
https://ncbi.nlm.nih.gov/pubmed/20881007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.068155
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