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Rational Design of a Selective Covalent Modifier of G Protein βγ Subunits
G protein-coupled receptors transduce signals through heterotrimeric G protein Gα and Gβγ subunits, both of which interact with downstream effectors to regulate cell function. Gβγ signaling has been implicated in the pathophysiology of several diseases, suggesting that Gβγ could be an important phar...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014279/ https://ncbi.nlm.nih.gov/pubmed/20881007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.068155 |
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