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Direct-reversible binding of small molecules to G protein βγ subunits
Heterotrimeric guanine nucleotide-binding proteins (G proteins) composed of three subunits α, β, γ mediate activation of multiple intracellular signaling cascades initiated by G protein-coupled receptors (GPCRs). Previously our laboratory identified small molecules that bind to Gβγ and interfere wit...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140432/ https://ncbi.nlm.nih.gov/pubmed/21621014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2011.05.010 |
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