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Direct-reversible binding of small molecules to G protein βγ subunits

Heterotrimeric guanine nucleotide-binding proteins (G proteins) composed of three subunits α, β, γ mediate activation of multiple intracellular signaling cascades initiated by G protein-coupled receptors (GPCRs). Previously our laboratory identified small molecules that bind to Gβγ and interfere wit...

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Главные авторы: Seneviratne, AMPB, Burroughs, Michael, Giralt, Ernest, Smrcka, Alan V.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140432/
https://ncbi.nlm.nih.gov/pubmed/21621014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2011.05.010
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