Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A

Phospholipase Cε (PLCε) is activated downstream of G protein–coupled receptors and receptor tyrosine kinases through direct interactions with small GTPases, including Rap1A and Ras. Although Ras has been reported to allosterically activate the lipase, it is not known whether Rap1A has the same abili...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Sieng, Monita, Selvia, Arielle F., Garland-Kuntz, Elisabeth E., Hopkins, Jesse B., Fisher, Isaac J., Marti, Andrea T., Lyon, Angeline M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2021
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864056/
https://ncbi.nlm.nih.gov/pubmed/32948655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015685
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