Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A

Phospholipase Cε (PLCε) is activated downstream of G protein–coupled receptors and receptor tyrosine kinases through direct interactions with small GTPases, including Rap1A and Ras. Although Ras has been reported to allosterically activate the lipase, it is not known whether Rap1A has the same abili...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Sieng, Monita, Selvia, Arielle F., Garland-Kuntz, Elisabeth E., Hopkins, Jesse B., Fisher, Isaac J., Marti, Andrea T., Lyon, Angeline M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864056/
https://ncbi.nlm.nih.gov/pubmed/32948655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015685
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