Direct observation of conformational dynamics of the PH domain in phospholipases Cϵ and β may contribute to subfamily-specific roles in regulation

Phospholipase C (PLC) enzymes produce second messengers that increase the intracellular Ca(2+) concentration and activate protein kinase C (PKC). These enzymes also share a highly conserved arrangement of core domains. However, the contributions of the individual domains to regulation are poorly und...

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Vydáno v:J Biol Chem
Hlavní autoři: Garland-Kuntz, Elisabeth E., Vago, Frank S., Sieng, Monita, Van Camp, Michelle, Chakravarthy, Srinivas, Blaine, Arryn, Corpstein, Clairissa, Jiang, Wen, Lyon, Angeline M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231117/
https://ncbi.nlm.nih.gov/pubmed/30242131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003656
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