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Direct observation of conformational dynamics of the PH domain in phospholipases Cϵ and β may contribute to subfamily-specific roles in regulation
Phospholipase C (PLC) enzymes produce second messengers that increase the intracellular Ca(2+) concentration and activate protein kinase C (PKC). These enzymes also share a highly conserved arrangement of core domains. However, the contributions of the individual domains to regulation are poorly und...
Guardat en:
| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6231117/ https://ncbi.nlm.nih.gov/pubmed/30242131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003656 |
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