Structure of phospholipase Cε reveals an integrated RA1 domain and previously unidentified regulatory elements

Phospholipase Cε (PLCε) generates lipid-derived second messengers at the plasma and perinuclear membranes in the cardiovascular system. It is activated in response to a wide variety of signals, such as those conveyed by Rap1A and Ras, through a mechanism that involves its C-terminal Ras association...

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Publicat a:Commun Biol
Autors principals: Rugema, Ngango Y., Garland-Kuntz, Elisabeth E., Sieng, Monita, Muralidharan, Kaushik, Van Camp, Michelle M., O’Neill, Hannah, Mbongo, William, Selvia, Arielle F., Marti, Andrea T., Everly, Amanda, McKenzie, Emmanda, Lyon, Angeline M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427993/
https://ncbi.nlm.nih.gov/pubmed/32796910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01178-8
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