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Molecular Mechanisms of PLCβ3 Autoinhibition
Phospholipase C β (PLCβ) enzymes are dramatically activated by heterotrimeric G proteins. Central to this response is the robust autoinhibition of PLCβ by an X–Y linker region within its catalytic core and by the Hα2′ helix in the C-terminal extension of the enzyme. The molecular mechanism of each a...
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| Publicado no: | Structure |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4308481/ https://ncbi.nlm.nih.gov/pubmed/25435326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.10.008 |
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