Intramolecular Electrostatic Interactions Contribute to Phospholipase Cβ3 Autoinhibition

Phospholipase Cβ (PLCβ) enzymes regulate second messenger production following the activation of G protein-coupled receptors (GPCRs). Under basal conditions, these enzymes are maintained in an autoinhibited state by multiple elements, including an insertion within the catalytic domain known as the X...

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Udgivet i:Cell Signal
Main Authors: Esquina, Candi M., Garland-Kuntz, Elisabeth E., Goldfarb, Daniel, McDonald, Emily K., Hudson, Brianna N., Lyon, Angeline M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686194/
https://ncbi.nlm.nih.gov/pubmed/31254604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2019.109349
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