Mechanism for autoinhibition and activation of the MORC3 ATPase

Microrchidia 3 (MORC3) is a human protein linked to autoimmune disorders, Down syndrome, and cancer. It is a member of a newly identified family of human ATPases with an uncharacterized mechanism of action. Here, we elucidate the molecular basis for inhibition and activation of MORC3. The crystal st...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Yi, Klein, Brianna J., Cox, Khan L., Bertulat, Bianca, Tencer, Adam H., Holden, Michael R., Wright, Gregory M., Black, Joshua, Cardoso, M. Cristina, Poirier, Michael G., Kutateladze, Tatiana G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442546/
https://ncbi.nlm.nih.gov/pubmed/30850548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819524116
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