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Molecular mechanism of the MORC4 ATPase activation

Human Microrchidia 4 (MORC4) is associated with acute and chronic pancreatitis, inflammatory disorders and cancer but it remains largely uncharacterized. Here, we describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activation. Enzymatic and binding assa...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tencer, Adam H., Cox, Khan L., Wright, Gregory M., Zhang, Yi, Petell, Christopher J., Klein, Brianna J., Strahl, Brian D., Black, Joshua C., Poirier, Michael G., Kutateladze, Tatiana G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596504/
https://ncbi.nlm.nih.gov/pubmed/33122719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19278-8
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