Molecular mechanism of the MORC4 ATPase activation

Human Microrchidia 4 (MORC4) is associated with acute and chronic pancreatitis, inflammatory disorders and cancer but it remains largely uncharacterized. Here, we describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activation. Enzymatic and binding assa...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Tencer, Adam H., Cox, Khan L., Wright, Gregory M., Zhang, Yi, Petell, Christopher J., Klein, Brianna J., Strahl, Brian D., Black, Joshua C., Poirier, Michael G., Kutateladze, Tatiana G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596504/
https://ncbi.nlm.nih.gov/pubmed/33122719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19278-8
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