A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23.

Por Mehta, Nehal, Loria, Paula M, Hobert, Oliver
Publicado em 2004

A Conserved Postsynaptic Transmembrane Protein Affecting Neuromuscular Signaling in Caenorhabditis elegans

Por Loria, Paula M., Hodgkin, Jonathan, Hobert, Oliver
Publicado no J Neurosci (2004)

Modulation of αCaMKII signaling by rapid ERα action

Por O’Neill, Erin E., Blewett, Alexis R., Loria, Paula M., Greene, Geoffrey L.
Publicado em 2008

Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel β-Arrestin Antagonist Activity

Por Menhaji-Klotz, Elnaz, Ward, Jessica, Brown, Janice A., Loria, Paula M., Tan, Carina, Hesp, Kevin D., Riccardi, Keith A., Litchfield, John, Boehm, Markus
Publicado no ACS Med Chem Lett (2020)

Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice

Por Murphy, Kate T., Ryall, James G., Snell, Sarah M., Nair, Lawrence, Koopman, René, Krasney, Philip A., Ibebunjo, Chikwendu, Holden, Kathryn S., Loria, Paula M., Salatto, Christopher T., Lynch, Gordon S.
Publicado em 2010

The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism

Por Eudy, Rena J, Sahasrabudhe, Vaishali, Sweeney, Kevin, Tugnait, Meera, King-Ahmad, Amanda, Near, Kristen, Loria, Paula, Banker, Mary Ellen, Piotrowski, David W, Boustany-Kari, Carine M
Publicado em 2011

PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy

Por Orena, Stephen, Maurer, Tristan S., She, Li, Eudy, Rena, Bernardo, Vincent, Dash, Darla, Loria, Paula, Banker, Mary E., Tugnait, Meera, Okerberg, Carlin V., Qian, Jessie, Boustany-Kari, Carine M.
Publicado em 2013

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro

Por Swedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros, Craik, David J.
Publicado no J Biol Chem (2016)

Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1)

Por Filipski, Kevin J., Sammons, Matthew F., Bhattacharya, Samit K., Panteleev, Jane, Brown, Janice A., Loria, Paula M., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Conn, Edward L., Song, Kun, Weng, Yan, Facemire, Carie, Jüppner, Harald, Clerin, Valerie
Publicado no ACS Med Chem Lett (2018)

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Por Lintner, Nathanael G., McClure, Kim F., Petersen, Donna, Londregan, Allyn T., Piotrowski, David W., Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M., Maguire, Bruce, Geoghegan, Kieran F., Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A., Dullea, Robert G., Cate, Jamie H. D.
Publicado no PLoS Biol (2017)

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

Por Lintner, Nathanael G., McClure, Kim F., Petersen, Donna, Londregan, Allyn T., Piotrowski, David W., Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M., Maguire, Bruce, Geoghegan, Kieran F., Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A., Dullea, Robert G., Cate, Jamie H. D.
Publicado no PLoS Biol (2018)

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

Por Boehm, Markus, Hepworth, David, Loria, Paula M., Norquay, Lisa D., Filipski, Kevin J., Chin, Janice E., Cameron, Kimberly O., Brenner, Martin, Bonnette, Peter, Cabral, Shawn, Conn, Edward, Ebner, David C., Gautreau, Denise, Hadcock, John, Lee, Esther C. Y., Mathiowetz, Alan M., Morin, Michelle, Rogers, Lucy, Smith, Aaron, VanVolkenburg, Maria, Carpino, Philip A.
Publicado em 2013

Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

Por Orr, Suvi T. M., Beveridge, Ramsay, Bhattacharya, Samit K., Cameron, Kimberly O., Coffey, Steven, Fernando, Dilinie, Hepworth, David, Jackson, Margaret V., Khot, Vishal, Kosa, Rachel, Lapham, Kimberly, Loria, Paula M., McClure, Kim F., Patel, Jigna, Rose, Colin, Saenz, James, Stock, Ingrid A., Storer, Gregory, von Volkenburg, Maria, Vrieze, Derek, Wang, Guoqiang, Xiao, Jun, Zhang, Yingxin
Publicado no ACS Med Chem Lett (2014)

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

Por Bhattacharya, Samit K., Andrews, Kim, Beveridge, Ramsay, Cameron, Kimberly O., Chen, Chiliu, Dunn, Matthew, Fernando, Dilinie, Gao, Hua, Hepworth, David, Jackson, V. Margaret, Khot, Vishal, Kong, Jimmy, Kosa, Rachel E., Lapham, Kimberly, Loria, Paula M., Londregan, Allyn T., McClure, Kim F., Orr, Suvi T. M., Patel, Jigna, Rose, Colin, Saenz, James, Stock, Ingrid A., Storer, Gregory, VanVolkenburg, Maria, Vrieze, Derek, Wang, Guoqiang, Xiao, Jun, Zhang, Yingxin
Publicado em 2014

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

Por Ammirati, Mark, Bagley, Scott W., Bhattacharya, Samit K., Buckbinder, Leonard, Carlo, Anthony A., Conrad, Rebecca, Cortes, Christian, Dow, Robert L., Dowling, Matthew S., El-Kattan, Ayman, Ford, Kristen, Guimarães, Cristiano R. W., Hepworth, David, Jiao, Wenhua, LaPerle, Jennifer, Liu, Shenping, Londregan, Allyn, Loria, Paula M., Mathiowetz, Alan M., Munchhof, Michael, Orr, Suvi T. M., Petersen, Donna N., Price, David A., Skoura, Athanasia, Smith, Aaron C., Wang, Jian
Publicado no ACS Med Chem Lett (2015)

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)

Por Huard, Kim, Brown, Janice, Jones, Jessica C., Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B., Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E., Magee, Thomas V., Uccello, Daniel P., Loria, Paula, Di, Li, Gosset, James R., Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A., Erion, Derek M.
Publicado no Sci Rep (2015)