Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example

[Image: see text] Orphan G protein-coupled receptors (oGPCRs) are a class of integral membrane proteins for which endogenous ligands or transmitters have not yet been discovered. Transgenic animal technologies have uncovered potential roles for many of these oGPCRs, providing new targets for the tre...

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Hlavní autoři: Boehm, Markus, Hepworth, David, Loria, Paula M., Norquay, Lisa D., Filipski, Kevin J., Chin, Janice E., Cameron, Kimberly O., Brenner, Martin, Bonnette, Peter, Cabral, Shawn, Conn, Edward, Ebner, David C., Gautreau, Denise, Hadcock, John, Lee, Esther C. Y., Mathiowetz, Alan M., Morin, Michelle, Rogers, Lucy, Smith, Aaron, VanVolkenburg, Maria, Carpino, Philip A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2013
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027148/
https://ncbi.nlm.nih.gov/pubmed/24900608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400275z
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