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Orphan GPCRs and neuromodulation
Most G protein-coupled receptors (GPCRs) started as orphan GPCRs. Matching them to known neuromodulators led to the elucidation of the broad diversity of the neuroreceptor families. Moreover, orphan GPCRs have also been used as targets to discover novel neuromodulators. These discoveries have had pr...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3474844/ https://ncbi.nlm.nih.gov/pubmed/23040803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.09.009 |
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