PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy

The mineralocorticoid receptor (MR) antagonists PF-03882845 and eplerenone were evaluated for renal protection against aldosterone-mediated renal disease in uninephrectomized Sprague-Dawley (SD) rats maintained on a high salt diet and receiving aldosterone by osmotic mini-pump for 27 days. Serum K(+...

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Detalhes bibliográficos
Main Authors: Orena, Stephen, Maurer, Tristan S., She, Li, Eudy, Rena, Bernardo, Vincent, Dash, Darla, Loria, Paula, Banker, Mary E., Tugnait, Meera, Okerberg, Carlin V., Qian, Jessie, Boustany-Kari, Carine M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796291/
https://ncbi.nlm.nih.gov/pubmed/24133446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2013.00115
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