Pharmacodynamic Model of Sodium–Glucose Transporter 2 (SGLT2) Inhibition: Implications for Quantitative Translational Pharmacology

Sodium–glucose co-transporter-2 (SGLT2) inhibitors are an emerging class of agents for use in the treatment of type 2 diabetes mellitus (T2DM). Inhibition of SGLT2 leads to improved glycemic control through increased urinary glucose excretion (UGE). In this study, a biologically based pharmacokineti...

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Detalhes bibliográficos
Main Authors: Maurer, Tristan S., Ghosh, Avijit, Haddish-Berhane, Nahor, Sawant-Basak, Aarti, Boustany-Kari, Carine M., She, Li, Leininger, Michael T., Zhu, Tong, Tugnait, Meera, Yang, Xin, Kimoto, Emi, Mascitti, Vincent, Robinson, Ralph P.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231856/
https://ncbi.nlm.nih.gov/pubmed/21870203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9297-2
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