Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

Por Orr, Suvi T. M., Beveridge, Ramsay, Bhattacharya, Samit K., Cameron, Kimberly O., Coffey, Steven, Fernando, Dilinie, Hepworth, David, Jackson, Margaret V., Khot, Vishal, Kosa, Rachel, Lapham, Kimberly, Loria, Paula M., McClure, Kim F., Patel, Jigna, Rose, Colin, Saenz, James, Stock, Ingrid A., Storer, Gregory, von Volkenburg, Maria, Vrieze, Derek, Wang, Guoqiang, Xiao, Jun, Zhang, Yingxin
Publicado no ACS Med Chem Lett (2014)

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Por Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Orr, Suvi T. M., Freeman-Cook, Kevin D., Londregan, Allyn T., Wei, Liuqing, Jennings, Sandra M., Herr, Michael, Coffey, Steven B., Jiao, Wenhua, Storer, Gregory, Hepworth, David, Wang, Jian, Lavergne, Sophie Y., Chin, Janice E., Hadcock, John R., Brenner, Martin B., Wolford, Angela C., Janssen, Ann M., Roush, Nicole S., Buxton, Joanne, Hinchey, Terri, Kalgutkar, Amit S., Sharma, Raman, Flynn, Declan A.
Publicado em 2012

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

Por Bhattacharya, Samit K., Andrews, Kim, Beveridge, Ramsay, Cameron, Kimberly O., Chen, Chiliu, Dunn, Matthew, Fernando, Dilinie, Gao, Hua, Hepworth, David, Jackson, V. Margaret, Khot, Vishal, Kong, Jimmy, Kosa, Rachel E., Lapham, Kimberly, Loria, Paula M., Londregan, Allyn T., McClure, Kim F., Orr, Suvi T. M., Patel, Jigna, Rose, Colin, Saenz, James, Stock, Ingrid A., Storer, Gregory, VanVolkenburg, Maria, Vrieze, Derek, Wang, Guoqiang, Xiao, Jun, Zhang, Yingxin
Publicado em 2014