Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

[Image: see text] Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achieved by modulating physicochemic...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Orr, Suvi T. M., Beveridge, Ramsay, Bhattacharya, Samit K., Cameron, Kimberly O., Coffey, Steven, Fernando, Dilinie, Hepworth, David, Jackson, Margaret V., Khot, Vishal, Kosa, Rachel, Lapham, Kimberly, Loria, Paula M., McClure, Kim F., Patel, Jigna, Rose, Colin, Saenz, James, Stock, Ingrid A., Storer, Gregory, von Volkenburg, Maria, Vrieze, Derek, Wang, Guoqiang, Xiao, Jun, Zhang, Yingxin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329598/
https://ncbi.nlm.nih.gov/pubmed/25699143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500414n
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