Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

[Image: see text] Takeda G-protein-coupled receptor 5 (TGR5) represents an exciting biological target for the potential treatment of diabetes and metabolic syndrome. A new class of high-throughput screening (HTS)-derived tetrahydropyrido[4,3-d]pyrimidine amide TGR5 agonists is disclosed. We describe...

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Bibliografiska uppgifter
Huvudupphovsmän: Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Orr, Suvi T. M., Freeman-Cook, Kevin D., Londregan, Allyn T., Wei, Liuqing, Jennings, Sandra M., Herr, Michael, Coffey, Steven B., Jiao, Wenhua, Storer, Gregory, Hepworth, David, Wang, Jian, Lavergne, Sophie Y., Chin, Janice E., Hadcock, John R., Brenner, Martin B., Wolford, Angela C., Janssen, Ann M., Roush, Nicole S., Buxton, Joanne, Hinchey, Terri, Kalgutkar, Amit S., Sharma, Raman, Flynn, Declan A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2012
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027551/
https://ncbi.nlm.nih.gov/pubmed/24900564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300277t
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