Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice

Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle wasting and weakness, leading to premature death from respiratory and/or cardiac failure. A clinically relevant question is whether myostatin inhibition can improve function of the diaphragm, which exhibits a severe an...

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Autori principali: Murphy, Kate T., Ryall, James G., Snell, Sarah M., Nair, Lawrence, Koopman, René, Krasney, Philip A., Ibebunjo, Chikwendu, Holden, Kathryn S., Loria, Paula M., Salatto, Christopher T., Lynch, Gordon S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2010
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861107/
https://ncbi.nlm.nih.gov/pubmed/20363926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090932
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