Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice

Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle wasting and weakness, leading to premature death from respiratory and/or cardiac failure. A clinically relevant question is whether myostatin inhibition can improve function of the diaphragm, which exhibits a severe an...

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Bibliografiske detaljer
Main Authors: Murphy, Kate T., Ryall, James G., Snell, Sarah M., Nair, Lawrence, Koopman, René, Krasney, Philip A., Ibebunjo, Chikwendu, Holden, Kathryn S., Loria, Paula M., Salatto, Christopher T., Lynch, Gordon S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861107/
https://ncbi.nlm.nih.gov/pubmed/20363926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090932
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