Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

[Image: see text] Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compound, 16 (PF-6260933) and a lead...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Ammirati, Mark, Bagley, Scott W., Bhattacharya, Samit K., Buckbinder, Leonard, Carlo, Anthony A., Conrad, Rebecca, Cortes, Christian, Dow, Robert L., Dowling, Matthew S., El-Kattan, Ayman, Ford, Kristen, Guimarães, Cristiano R. W., Hepworth, David, Jiao, Wenhua, LaPerle, Jennifer, Liu, Shenping, Londregan, Allyn, Loria, Paula M., Mathiowetz, Alan M., Munchhof, Michael, Orr, Suvi T. M., Petersen, Donna N., Price, David A., Skoura, Athanasia, Smith, Aaron C., Wang, Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2015
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645242/
https://ncbi.nlm.nih.gov/pubmed/26617966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00215
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