Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment

[Image: see text] Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic drugs. As part of the evaluation of MAP4K4 as a novel antidiabetic target, a tool compound, 16 (PF-6260933) and a lead...

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發表在:ACS Med Chem Lett
Main Authors: Ammirati, Mark, Bagley, Scott W., Bhattacharya, Samit K., Buckbinder, Leonard, Carlo, Anthony A., Conrad, Rebecca, Cortes, Christian, Dow, Robert L., Dowling, Matthew S., El-Kattan, Ayman, Ford, Kristen, Guimarães, Cristiano R. W., Hepworth, David, Jiao, Wenhua, LaPerle, Jennifer, Liu, Shenping, Londregan, Allyn, Loria, Paula M., Mathiowetz, Alan M., Munchhof, Michael, Orr, Suvi T. M., Petersen, Donna N., Price, David A., Skoura, Athanasia, Smith, Aaron C., Wang, Jian
格式: Artigo
語言:Inglês
出版: American Chemical Society 2015
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645242/
https://ncbi.nlm.nih.gov/pubmed/26617966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00215
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