Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1)

[Image: see text] Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormona...

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Publicado en:ACS Med Chem Lett
Main Authors: Filipski, Kevin J., Sammons, Matthew F., Bhattacharya, Samit K., Panteleev, Jane, Brown, Janice A., Loria, Paula M., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Conn, Edward L., Song, Kun, Weng, Yan, Facemire, Carie, Jüppner, Harald, Clerin, Valerie
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2018
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949730/
https://ncbi.nlm.nih.gov/pubmed/29795756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00013
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