Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1)

[Image: see text] Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormona...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Filipski, Kevin J., Sammons, Matthew F., Bhattacharya, Samit K., Panteleev, Jane, Brown, Janice A., Loria, Paula M., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Conn, Edward L., Song, Kun, Weng, Yan, Facemire, Carie, Jüppner, Harald, Clerin, Valerie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2018
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949730/
https://ncbi.nlm.nih.gov/pubmed/29795756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00013
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg