Identification of the First Sodium Binding Site of the Phosphate Cotransporter NaPi-IIa (SLC34A1)

Transporters of the SLC34 family (NaPi-IIa,b,c) catalyze uptake of inorganic phosphate (P(i)) in renal and intestinal epithelia. The transport cycle requires three Na(+) ions and one divalent P(i) to bind before a conformational change enables translocation, intracellular release of the substrates,...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Fenollar-Ferrer, Cristina, Forster, Ian C., Patti, Monica, Knoepfel, Thomas, Werner, Andreas, Forrest, Lucy R.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2015
Assuntos:
Channels and Transporters
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457043/
https://ncbi.nlm.nih.gov/pubmed/25992725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.054
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