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Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion

The sodium-phosphate cotransporter NPT2a plays a key role in the reabsorption of filtered phosphate in proximal renal tubules, thereby critically contributing to phosphate homeostasis. Inadequate urinary phosphate excretion can lead to severe hyperphosphatemia as in tumoral calcinosis and chronic ki...

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Foilsithe in:J Clin Invest
Main Authors: Clerin, Valerie, Saito, Hiroshi, Filipski, Kevin J., Nguyen, An Hai, Garren, Jeonifer, Kisucka, Janka, Reyes, Monica, Jüppner, Harald
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685737/
https://ncbi.nlm.nih.gov/pubmed/32853180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135665
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