Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion

The sodium-phosphate cotransporter NPT2a plays a key role in the reabsorption of filtered phosphate in proximal renal tubules, thereby critically contributing to phosphate homeostasis. Inadequate urinary phosphate excretion can lead to severe hyperphosphatemia as in tumoral calcinosis and chronic ki...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Clerin, Valerie, Saito, Hiroshi, Filipski, Kevin J., Nguyen, An Hai, Garren, Jeonifer, Kisucka, Janka, Reyes, Monica, Jüppner, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685737/
https://ncbi.nlm.nih.gov/pubmed/32853180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135665
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