Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion

The sodium-phosphate cotransporter NPT2a plays a key role in the reabsorption of filtered phosphate in proximal renal tubules, thereby critically contributing to phosphate homeostasis. Inadequate urinary phosphate excretion can lead to severe hyperphosphatemia as in tumoral calcinosis and chronic ki...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Clerin, Valerie, Saito, Hiroshi, Filipski, Kevin J., Nguyen, An Hai, Garren, Jeonifer, Kisucka, Janka, Reyes, Monica, Jüppner, Harald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685737/
https://ncbi.nlm.nih.gov/pubmed/32853180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135665
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