Farnesyl Diphosphate Synthase Inhibitors With Unique Ligand-Binding Geometries

Por Liu, Yi-Liang, Cao, Rong, Wang, Yang, Oldfield, Eric
Publicado no ACS Med Chem Lett (2015)

Functional Role of Dimerization of Human Peptidylarginine Deiminase 4 (PAD4)

Por Liu, Yi-Liang, Chiang, Yu-Hsiu, Liu, Guang-Yaw, Hung, Hui-Chih
Publicado em 2011

Critical Factors Governing the Difference in Antizyme-Binding Affinities between Human Ornithine Decarboxylase and Antizyme Inhibitor

Por Liu, Yen-Chin, Liu, Yi-Liang, Su, Jia-Yang, Liu, Guang-Yaw, Hung, Hui-Chih
Publicado em 2011

Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening

Por Lindert, Steffen, Zhu, Wei, Liu, Yi-Liang, Pang, Ran, Oldfield, Eric, McCammon, J Andrew
Publicado em 2013

Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation

Por Guerra, Francisco, Wang, Ke, Li, Jikun, Wang, Weixue, Liu, Yi-Liang, Amin, Shivani, Oldfield, Eric
Publicado em 2014

Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

Por Liu, Yi-Liang, Lindert, Steffen, Zhu, Wei, Wang, Ke, McCammon, J. Andrew, Oldfield, Eric
Publicado em 2014

Functional Roles of the Dimer-Interface Residues in Human Ornithine Decarboxylase

Por Lee, Chien-Yun, Liu, Yi-Liang, Lin, Chih-Li, Liu, Guang-Yaw, Hung, Hui-Chih
Publicado em 2014

Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation

Por Huang, Kai-Fa, Liu, Yi-Liang, Cheng, Wei-Ju, Ko, Tzu-Ping, Wang, Andrew H.-J.
Publicado em 2005

Bioorganometallic mechanism of action, and inhibition, of IspH

Por Wang, Weixue, Wang, Ke, Liu, Yi-Liang, No, Joo-Hwan, Li, Jikun, Nilges, Mark J., Oldfield, Eric
Publicado em 2010

Structure, Function and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase

Por Desai, Janish, Liu, Yi-Liang, Wei, Hongli, Liu, Weidong, Ko, Tzu-Ping, Guo, Rey-Ting, Oldfield, Eric
Publicado no ChemMedChem (2016)

Determinants of the Differential Antizyme-Binding Affinity of Ornithine Decarboxylase

Por Liu, Yen-Chin, Hsu, Den-Hua, Huang, Chi-Liang, Liu, Yi-Liang, Liu, Guang-Yaw, Hung, Hui-Chih
Publicado em 2011

Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets

Por Lin, Fu-Yang, Liu, Yi-Liang, Li, Kai, Cao, Rong, Zhu, Wei, Axelson, Jordan, Pang, Ran, Oldfield, Eric
Publicado em 2012

Functional Roles of the Non-Catalytic Calcium-Binding Sites in the N-Terminal Domain of Human Peptidylarginine Deiminase 4

Por Liu, Yi-Liang, Tsai, I-Chen, Chang, Chia-Wei, Liao, Ya-Fan, Liu, Guang-Yaw, Hung, Hui-Chih
Publicado em 2013

Molecular Interplay between the Dimer Interface and the Substrate-Binding Site of Human Peptidylarginine Deiminase 4

Por Lee, Chien-Yun, Lin, Chu-Cheng, Liu, Yi-Liang, Liu, Guang-Yaw, Liu, Jyung-Hurng, Hung, Hui-Chih
Publicado no Sci Rep (2017)

Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase

Por Ricci, Clarisse G., Liu, Yi-Liang, Zhang, Yonghui, Wang, Yang, Zhu, Wei, Oldfield, Eric, McCammon, J. Andrew
Publicado no Biochemistry (2016)

Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System Based Therapeutics

Por Lin, Fu-Yang, Zhang, Yonghui, Hensler, Mary, Liu, Yi-Liang, Chow, Ohn A., Zhu, Wei, Wang, Ke, Pang, Ran, Thienphrapa, Wdee, Nizet, Victor, Oldfield, Eric
Publicado em 2012

Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

Por Liu, Yi-Liang, Guerra, Francisco, Wang, Ke, Wang, Weixue, Li, Jikun, Huang, Cancan, Zhu, Wei, Houlihan, Kevin, Li, Zhi, Zhang, Yong, Nair, Satish K., Oldfield, Eric
Publicado em 2012

Mechanism of action and inhibition of dehydrosqualene synthase

Por Lin, Fu-Yang, Liu, Chia-I, Liu, Yi-Liang, Zhang, Yonghui, Wang, Ke, Jeng, Wen-Yih, Ko, Tzu-Ping, Cao, Rong, Wang, Andrew H.-J., Oldfield, Eric
Publicado em 2010

Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis

Por Zhang, Yonghui, Zhu, Wei, Liu, Yi-Liang, Wang, Hong, Wang, Ke, Li, Kai, No, Joo Hwan, Ayong, Lawrence, Gulati, Anmol, Pang, Ran, Freitas-Junior, Lucio, Morita, Craig T., Oldfield, Eric
Publicado em 2013

A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin

Por Xia, Yifeng, Liu, Yi-Liang, Xie, Yonghua, Zhu, Wei, Guerra, Francisco, Shen, Shen, Yeddula, Narayana, Fischer, Wolfgang, Low, William, Zhou, Xiaoying, Zhang, Yonghui, Oldfield, Eric, Verma, Inder M.
Publicado no Sci Transl Med (2014)