Mechanism of action and inhibition of dehydrosqualene synthase

“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. Here, we report the structures of Staphylococcus aureus dehydrosqualene synth...

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Bibliographic Details
Main Authors:	Lin, Fu-Yang, Liu, Chia-I, Liu, Yi-Liang, Zhang, Yonghui, Wang, Ke, Jeng, Wen-Yih, Ko, Tzu-Ping, Cao, Rong, Wang, Andrew H.-J., Oldfield, Eric
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2010
Subjects:	Physical Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3003041/ https://ncbi.nlm.nih.gov/pubmed/21098670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010907107
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Mechanism of action and inhibition of dehydrosqualene synthase

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