Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus

Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most active compounds are halogen-substituted phosphon...

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Detalhes bibliográficos
Main Authors: Song, Yongcheng, Lin, Fu-Yang, Yin, Fenglin, Hensler, Mary, Poveda, Carlos A. Rodrígues, Mukkamala, Dushyant, Cao, Rong, Wang, Hong, Morita, Craig T., Pacanowska, Dolores González, Nizet, Victor, Oldfield, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765255/
https://ncbi.nlm.nih.gov/pubmed/19191557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801023u
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