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2-Alkylaminoethyl-1,1-Bisphosphonic Acids Are Potent Inhibitors of the Enzymatic Activity of Trypanosoma cruzi Squalene Synthase

As part of our efforts aimed at searching for new antiparasitic agents, the effect of representative 2-alkylaminoethyl-1,1-bisphosphonic acids on Trypanosoma cruzi squalene synthase (TcSQS) was investigated. These compounds had proven to be potent inhibitors of T. cruzi. This cellular activity had b...

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Detalhes bibliográficos
Main Authors: Rodrígues-Poveda, Carlos A., González-Pacanowska, Dolores, Szajnman, Sergio H., Rodríguez, Juan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421570/
https://ncbi.nlm.nih.gov/pubmed/22585217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00796-12
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