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Synthesis and Biological Evaluation of New 2-Alkylaminoethyl-1,1-Bisphosphonic Acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase

The effect of long chain 2-alkylaminoethyl-1,1-bisphosphonates against proliferation of the clinically more relevant form of Trypanosoma cruzi, the etiologic agent of American trypanosomiasis (Chagas’ disease), and against tachyzoites of Toxoplasma gondii was investigated. Particularly, compound 26...

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Detalhes bibliográficos
Main Authors: Rosso, Valeria S., Szajnman, Sergio H., Malayil, Leena, Galizzi, Melina, Moreno, Silvia N. J., Docampo, Roberto, Rodriguez, Juan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071284/
https://ncbi.nlm.nih.gov/pubmed/21419634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.02.037
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