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Synthesis and Biological Evaluation of New 2-Alkylaminoethyl-1,1-Bisphosphonic Acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase

The effect of long chain 2-alkylaminoethyl-1,1-bisphosphonates against proliferation of the clinically more relevant form of Trypanosoma cruzi, the etiologic agent of American trypanosomiasis (Chagas’ disease), and against tachyzoites of Toxoplasma gondii was investigated. Particularly, compound 26...

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書誌詳細
主要な著者: Rosso, Valeria S., Szajnman, Sergio H., Malayil, Leena, Galizzi, Melina, Moreno, Silvia N. J., Docampo, Roberto, Rodriguez, Juan B.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071284/
https://ncbi.nlm.nih.gov/pubmed/21419634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.02.037
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