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1-(Fluoroalkylidene)-1,1-bisphosphonic Acids are Potent and Selective Inhibitors of the Enzymatic Activity of Toxoplasma gondii Farnesyl Pyrophosphate Synthase

α-Fluorinated-1,1-bisphosphonic acids derived from fatty acids were designed, synthesized and biologically evaluated against Trypanosoma cruzi, the etiologic agent of Chagas disease and against Toxoplasma gondii, the responsible agent of toxoplasmosis and also towards the target parasitic enzymes fa...

詳細記述

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書誌詳細
主要な著者: Szajnman, Sergio H., Rosso, Valeria S., Malayil, Leena, Smith, Alyssa, Moreno, Silvia N. J., Docampo, Roberto, Rodriguez, Juan B.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458512/
https://ncbi.nlm.nih.gov/pubmed/22215028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1ob06602a
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