Synthesis and Biological Evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase

The effect of a series of 2-alkylaminoethyl-1,1-bisphosphonic acids against proliferation of the clinically more relevant form of Trypanosoma cruzi, the etiologic agent of American trypanosomiasis (Chagas’ disease), and against tachyzoites of Toxoplasma gondii has been studied. Most of these drugs e...

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Detalhes bibliográficos
Main Authors: Szajnman, Sergio H., García Liñares, Guadalupe E., Li, Zhu-Hong, Jiang, Cuiying, Galizzi, Melina, Bontempi, Esteban J., Ferella, Marcela, Moreno, Silvia N. J., Docampo, Roberto, Rodriguez, Juan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2330165/
https://ncbi.nlm.nih.gov/pubmed/18096393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.12.010
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