Design, Synthesis, Calorimetry and Crystallographic analysis of 2-Alkylaminoethyl-1,1-Bisphosphonates as inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

Eitemau Tebyg

• Synthesis and Biological Evaluation of New 2-Alkylaminoethyl-1,1-Bisphosphonic Acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase
  gan: Rosso, Valeria S., et al.
  Cyhoeddwyd: (2011)
• Synthesis and Biological Evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase
  gan: Szajnman, Sergio H., et al.
  Cyhoeddwyd: (2007)
• Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer
  gan: Huang, Chuan-Hsiang, et al.
  Cyhoeddwyd: (2010)
• Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates
  gan: Aripirala, Srinivas, et al.
  Cyhoeddwyd: (2014)
• 2-Alkylaminoethyl-1,1-Bisphosphonic Acids Are Potent Inhibitors of the Enzymatic Activity of Trypanosoma cruzi Squalene Synthase
  gan: Rodrígues-Poveda, Carlos A., et al.
  Cyhoeddwyd: (2012)