Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

Eitemau Tebyg

• Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates
  gan: Aripirala, Srinivas, et al.
  Cyhoeddwyd: (2014)
• Design, Synthesis, Calorimetry and Crystallographic analysis of 2-Alkylaminoethyl-1,1-Bisphosphonates as inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase
  gan: Aripirala, Srinivas, et al.
  Cyhoeddwyd: (2012)
• Farnesyl Diphosphate Synthase Localizes to the Cytoplasm of Trypanosoma cruzi and T.brucei
  gan: Ferella, Marcela, et al.
  Cyhoeddwyd: (2008)
• Farnesyl diphosphate synthase, the target for nitrogen-containing bisphosphonate drugs, is a peroxisomal enzyme in the model system Dictyostelium discoideum
  gan: Nuttall, James M., et al.
  Cyhoeddwyd: (2012)
• Synthesis and Biological Evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting Farnesyl Diphosphate Synthase
  gan: Szajnman, Sergio H., et al.
  Cyhoeddwyd: (2007)