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Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer

Bisphosphonates (BPs) are a class of compounds that have been used extensively in the treatment of osteoporosis and malignancy-related hypercalcemia. Some of these compounds act through inhibition of farnesyl diphosphate synthase (FPPS), a key enzyme in the synthesis of isoprenoids. Recently, nitrog...

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Bibliografske podrobnosti
Main Authors: Huang, Chuan-Hsiang, Gabelli, Sandra B., Oldfield, Eric, Amzel, L. Mario
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018326/
https://ncbi.nlm.nih.gov/pubmed/19876942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22614
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