Design, Synthesis, Calorimetry and Crystallographic analysis of 2-Alkylaminoethyl-1,1-Bisphosphonates as inhibitors of Trypanosoma cruzi Farnesyl Diphosphate Synthase

Linear 2-alkylaminoethyl-1,1-bisphosphonates are effective agents against proliferation of Trypanosoma cruzi--the etiologic agent of American trypanosomiasis (Chagas disease)--exhibiting IC(50) values in the nanomolar range against the parasites. This activity is associated with inhibition at the lo...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Aripirala, Srinivas, Szajnman, Sergio H., Jakoncic, Jean, Rodriguez, Juan B., Docampo, Roberto, Gabelli, Sandra B., Amzel, L. Mario
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710095/
https://ncbi.nlm.nih.gov/pubmed/22715997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300425y
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