Phosphonosulfonates Are Potent, Selective Inhibitors of Dehydrosqualene Synthase and Staphyloxanthin Biosynthesis in Staphylococcus aureus

Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most active compounds are halogen-substituted phosphon...

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Main Authors: Song, Yongcheng, Lin, Fu-Yang, Yin, Fenglin, Hensler, Mary, Poveda, Carlos A. Rodrígues, Mukkamala, Dushyant, Cao, Rong, Wang, Hong, Morita, Craig T., Pacanowska, Dolores González, Nizet, Victor, Oldfield, Eric
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765255/
https://ncbi.nlm.nih.gov/pubmed/19191557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801023u
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